MolNFT v1 · #190364 · protein

Cbp-brd complexed with NEO2734

7WX2 · Creb-binding protein: “Cbp-brd complexed with NEO2734”. X-ray diffraction, 1 ligand (7OW), 1 pocket (best druggability 0.50). MolNFT v1 #190364 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7WX2
Type: protein
Length: 117 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Creb-binding protein
EC: 2.3.1.48, 2.3.1.-
UniProt: Q92793
Ligands: 7OW
Pockets: 1 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 67% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Creb-binding protein (EC 2.3.1.48, 2.3.1.-)	protein	117	67% helix, 0% strand	Q92793

Ligands and binding sites

7OW · 1,3-dimethyl-5-[2-(oxan-4-yl)-3-[2-(trifluoromethyloxy)ethyl]benzimidazol-5-yl]pyridin-2-one · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	110	0.50	0.80	22	7OW

Compared structures

7WX2 · CBP-BrD complexed with NEO2734 · the same entry in another collection · chain A against A, TM-score 1.00
Q92793 · AlphaFold monomer V2.0 prediction for creb-binding protein (Q92793) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92793
Elsewhere: RCSB PDB 7WX2 · PDBe 7WX2 · UniProt Q92793

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.