MolNFT v1 · #19025 · protein
Crystal structure of mammalian POLY(A) polymerase
1Q79 · POLY(A) polymerase alpha: “Crystal structure of mammalian POLY(A) polymerase”. X-ray diffraction, 2 ligands (3AT, MN), 4 pockets (best druggability 0.62). MolNFT v1 #19025 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1Q79
- Type
- protein
- Length
- 470 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- POLY(A) polymerase alpha
- EC
- 2.7.7.19
- UniProt
- P25500
- Ligands
- 3AT, MN
- Pockets
- 4 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | POLY(A) polymerase alpha (EC 2.7.7.19) | protein | 470 | 45% helix, 17% strand | P25500 |
Ligands and binding sites
- 3AT · 3'-deoxyadenosine-5'-triphosphate · ligand · chains A
- MN · Manganese (II) ion · metal · 2 copies · chains A
- GOL · Glycerol · additive · 5 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 516 | 0.62 | 0.75 | 56 | MN, 3AT |
| 2 | 102 | 0.40 | 0.76 | 18 | empty |
| 3 | 54 | 0.36 | 0.79 | 20 | empty |
| 4 | 52 | 0.29 | 0.75 | 14 | empty |
Modifications
Observed in the structure: 3 modified (oxidation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25500
- Elsewhere: RCSB PDB 1Q79 · PDBe 1Q79 · UniProt P25500
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