MolNFT v1 · #19024 · protein
Crystal structure of POLY(A) polymerase in complex with 3'- datp and magnesium chloride
1Q78 · POLY(A) polymerase alpha: “Crystal structure of POLY(A) polymerase in complex with 3'- datp and magnesium chloride”. X-ray diffraction, 2 ligands (3AT, MG), 3 pockets (best druggability 0.63). MolNFT v1 #19024 on GenesisL1: 3D…
- PDB
- 1Q78
- Type
- protein
- Length
- 470 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- POLY(A) polymerase alpha
- EC
- 2.7.7.19
- UniProt
- P25500
- Ligands
- 3AT, MG
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | POLY(A) polymerase alpha (EC 2.7.7.19) | protein | 470 | 44% helix, 17% strand | P25500 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 543 | 0.63 | 0.75 | 52 | MG, 3AT |
| 2 | 93 | 0.39 | 0.77 | 18 | empty |
| 3 | 61 | 0.38 | 0.79 | 18 | empty |
Modifications
Observed in the structure: 2 modified (oxidation).
Compared structures
- 1Q78 · Crystal structure of poly(A) polymerase in complex with 3'-dATP and magnesium chloride · the same entry in another collection · chain A against A, TM-score 1.00
- P25500 · AlphaFold monomer V2.0 prediction for POLY(A) polymerase alpha (P25500) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25500
- Elsewhere: RCSB PDB 1Q78 · PDBe 1Q78 · UniProt P25500
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