MolNFT v1 · #190227 · protein

Cryo-EM structure of full-length NUP188

7WO9 · Nucleoporin NUP188: “Cryo-EM structure of full-length NUP188”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #190227 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7WO9
Type: protein
Length: 1,581 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoporin NUP188
UniProt: P52593
Pockets: 20 · best druggability 0.81

Structure

electron microscopy · 1 distinct chain · 65% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleoporin NUP188	protein	1581	65% helix, 3% strand	P52593

Pockets

20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	269	0.81	0.92	41	empty
2	1017	0.80	0.82	102	empty
3	312	0.80	0.91	50	empty
4	309	0.79	0.89	48	empty
5	234	0.68	0.84	26	empty

Compared structures

7WO9 · Cryo-EM structure of full-length Nup188 · the same entry in another collection · chain A against A, TM-score 1.00
P52593 · AlphaFold monomer V2.0 prediction for nucleoporin NUP188 (P52593) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52593
Elsewhere: RCSB PDB 7WO9 · PDBe 7WO9 · UniProt P52593

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