MolNFT v1 · #190120 · protein

Human neutrophil elastase in-complex with ecotin peptide

7WHU: “Human neutrophil elastase in-complex with ecotin peptide”. X-ray diffraction, 4 ligands (NAG, FUC, BMA). MolNFT v1 #190120 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7WHU
Type: protein
Length: 904 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P08246
Ligands: NAG, FUC, BMA, SO4

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D, A, B, C	—	protein	218	—	P08246
E, F, G, H	—	protein	8	—	—

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 15 copies · chains B, D, C, A
FUC · alpha-L-fucopyranose · sugar · 7 copies · chains B, D, A, C
BMA · beta-D-mannopyranose · sugar
SO4 · Sulfate ion · ion · 5 copies · chains D, B, C
GOL · Glycerol · additive · 6 copies · chains D, A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7WHU · Human Neutrophil Elastase in-complex with Ecotin Peptide · the same entry in another collection · chain H against H, TM-score 1.00
P08246 · AlphaFold monomer V2.0 prediction for neutrophil elastase (P08246) · a predicted model of the same protein · chain C against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08246
Elsewhere: RCSB PDB 7WHU · PDBe 7WHU · UniProt P08246

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