MolNFT v1 · #190066 · protein + DNA + RNA
Structure of csy-ACRIF24-dsdna
7WE6 · CRISPR type I-F/YPEST-associated protein CSY2: “Structure of csy-ACRIF24-dsdna”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #190066 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7WE6
- Type
- protein + DNA + RNA
- Length
- 6,373 residues
- Chains
- 26
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CRISPR type I-F/YPEST-associated protein CSY2; CRISPR-associated protein CSY3; Type I-F…
- UniProt
- B3G161, A0A659BSG0, A0A0C6F3X3, A0A3A8DDU9
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 15 distinct chains · 28% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, L | CRISPR type I-F/YPEST-associated protein CSY2 | protein | 305 | 22% helix, 29% strand | B3G161 |
| C, M | CRISPR-associated protein CSY3 | protein | 293 | 25% helix, 27% strand | A0A659BSG0 |
| D, O | CRISPR-associated protein CSY3 | protein | 334 | 24% helix, 25% strand | A0A659BSG0 |
| E | CRISPR-associated protein CSY3 | protein | 337 | 24% helix, 24% strand | A0A659BSG0 |
| F, P | CRISPR-associated protein CSY3 | protein | 335 | 25% helix, 24% strand | A0A659BSG0 |
| G | CRISPR-associated protein CSY3 | protein | 329 | 26% helix, 26% strand | A0A659BSG0 |
| H | CRISPR-associated protein CSY3 | protein | 332 | 27% helix, 25% strand | A0A659BSG0 |
| I, S | Type I-F CRISPR-associated endoribonuclease CAS6/CSY4 | protein | 187 | 27% helix, 22% strand | A0A0C6F3X3 |
| N | CRISPR-associated protein CSY3 | protein | 335 | 24% helix, 24% strand | A0A659BSG0 |
| Q, R | CRISPR-associated protein CSY3 | protein | 333 | 26% helix, 24% strand | A0A659BSG0 |
| U, V | ACRIF24 | protein | 227 | 30% helix, 22% strand | — |
| J, T | RNA (60-mer) | rna | 60 | — | — |
| A, X | Type I-F CRISPR-associated protein CSY1 | protein | 424 | 53% helix, 7% strand | A0A3A8DDU9 |
| Y, K | DNA (5'-D(P*GP*GP*AP*TP*GP*GP*CP*TP*TP*CP*C)-3') | dna | 11 | — | — |
| Z, W | DNA-R | dna | 11 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 841 | 0.86 | 0.89 | 115 | empty |
| 2 | 1195 | 0.86 | 0.87 | 113 | empty |
| 3 | 744 | 0.86 | 0.89 | 99 | empty |
| 4 | 673 | 0.85 | 0.89 | 74 | empty |
| 5 | 705 | 0.84 | 0.88 | 96 | empty |
Interfaces
66 interfaces between chains.
- L–X · 3345 Ų buried · 33 hydrogen bonds · protein-protein
- B–A · 3241 Ų buried · 32 hydrogen bonds · protein-protein
- E–F · 2083 Ų buried · 23 hydrogen bonds · protein-protein
- N–O · 1982 Ų buried · 24 hydrogen bonds · protein-protein
- O–P · 1941 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 7WE6 · Structure of Csy-AcrIF24-dsDNA · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B3G161
- Every structure of UniProt A0A659BSG0
- Every structure of UniProt A0A0C6F3X3
- Every structure of UniProt A0A3A8DDU9
- Elsewhere: RCSB PDB 7WE6 · PDBe 7WE6 · UniProt B3G161 · UniProt A0A659BSG0 · UniProt A0A0C6F3X3 · UniProt A0A3A8DDU9
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