MolNFT v1 · #190006 · protein + RNA
Structure of CAS7-11 in complex with guide RNA and target RNA
7WAH · Crrna (39-mer): “Structure of CAS7-11 in complex with guide RNA and target RNA”. Electron microscopy, 1 ligand (ZN), 20 pockets (best druggability 0.80). MolNFT v1 #190006 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7WAH
- Type
- protein + RNA
- Length
- 1,535 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Crrna (39-mer); Tgrna (5'- R(P*UP*AP*CP*CP*CP*AP*UP*GP*UP*CP*GP*AP*AP*GP*AP*CP*AP*AP*CP*AP…
- UniProt
- A0A401FT36
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 3 distinct chains · 23% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R | Crrna (39-mer) | rna | 39 | — | — |
| D | Tgrna (5'- R(P*UP*AP*CP*CP*CP*AP*UP*GP*UP*CP*GP*AP*AP*GP*AP*CP*AP*AP*CP*AP*AP*AP *G)-3') | rna | 23 | — | — |
| A | CRISPR-associated ramp family protein | protein | 1473 | 23% helix, 30% strand | A0A401FT36 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 710 | 0.80 | 0.84 | 77 | empty |
| 2 | 785 | 0.78 | 0.82 | 69 | empty |
| 3 | 661 | 0.78 | 0.83 | 73 | empty |
| 4 | 562 | 0.77 | 0.84 | 55 | empty |
| 5 | 806 | 0.76 | 0.80 | 70 | empty |
Interfaces
3 interfaces between chains.
- R–A · 6804 Ų buried · 204 hydrogen bonds · protein-nucleic
- D–A · 2133 Ų buried · 31 hydrogen bonds · protein-nucleic
- R–D · 987 Ų buried · 60 hydrogen bonds · nucleic-nucleic
Compared structures
- 7WAH · Structure of Cas7-11 in complex with guide RNA and target RNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A401FT36
- Elsewhere: RCSB PDB 7WAH · PDBe 7WAH · UniProt A0A401FT36
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