MolNFT v1 · #18999 · protein
Crystal structure of a truncated form of fkpa from escherichia COLI
1Q6H · Fkbp-type peptidyl-prolyl cis-trans isomerase fkpa: “Crystal structure of a truncated form of fkpa from escherichia COLI”. X-ray diffraction, 4 pockets (best druggability 0.34). MolNFT v1 #18999 on GenesisL1: 3D structure, binding…
- PDB
- 1Q6H
- Type
- protein
- Length
- 420 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fkbp-type peptidyl-prolyl cis-trans isomerase fkpa
- EC
- 5.2.1.8
- UniProt
- P45523
- Pockets
- 4 · best druggability 0.34
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Fkbp-type peptidyl-prolyl cis-trans isomerase fkpa (EC 5.2.1.8) | protein | 210 | 47% helix, 21% strand | P45523 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.34 | 0.76 | 13 | empty |
| 2 | 54 | 0.31 | 0.75 | 11 | empty |
| 3 | 65 | 0.30 | 0.73 | 12 | empty |
| 4 | 52 | 0.26 | 0.73 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 2312 Ų buried · 27 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 1Q6H · Crystal structure of a truncated form of FkpA from Escherichia coli · the same entry in another collection · chain A against A, TM-score 1.00
- P45523 · AlphaFold monomer V2.0 prediction for fkbp-type peptidyl-prolyl cis- trans isomerase fkpa… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P45523
- Elsewhere: RCSB PDB 1Q6H · PDBe 1Q6H · UniProt P45523
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