MolNFT v1 · #189722 · protein

Crystal strcuture of the tandem B-box domains of constans

7VSQ · Zinc finger protein constans: “Crystal strcuture of the tandem B-box domains of constans”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.60). MolNFT v1 #189722 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7VSQ
Type: protein
Length: 262 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Zinc finger protein constans
UniProt: Q39057
Ligands: ZN
Pockets: 1 · best druggability 0.60

Structure

x-ray diffraction · 3 distinct chains · 22% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Zinc finger protein constans	protein	89	20% helix, 25% strand	Q39057
B	Zinc finger protein constans	protein	87	24% helix, 22% strand	Q39057
C	Zinc finger protein constans	protein	86	21% helix, 27% strand	Q39057

Ligands and binding sites

ZN · Zinc ion · metal · 12 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	550	0.60	0.73	49	empty

Interfaces

3 interfaces between chains.

A–B · 155 Å² buried · 3 hydrogen bonds · protein-protein
A–C · 152 Å² buried · 1 hydrogen bond · protein-protein
B–C · 37 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7VSQ · Crystal strcuture of the tandem B-Box domains of CONSTANS · the same entry in another collection · chain A against A, TM-score 1.00
Q39057 · AlphaFold monomer V2.0 prediction for zinc finger protein constans (Q39057) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q39057
Elsewhere: RCSB PDB 7VSQ · PDBe 7VSQ · UniProt Q39057

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