MolNFT v1 · #189721 · protein
Crystal strcuture of the tandem B-box domains of COL2
7VSP · Zinc finger protein constans-like 2: “Crystal strcuture of the tandem B-box domains of COL2”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.65). MolNFT v1 #189721 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7VSP
- Type
- protein
- Length
- 271 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Zinc finger protein constans-like 2
- UniProt
- Q96502
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 3 distinct chains · 26% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Zinc finger protein constans-like 2 | protein | 90 | 27% helix, 23% strand | Q96502 |
| B | Zinc finger protein constans-like 2 | protein | 89 | 25% helix, 22% strand | Q96502 |
| C | Zinc finger protein constans-like 2 | protein | 92 | 26% helix, 24% strand | Q96502 |
Ligands and binding sites
- ZN · Zinc ion · metal · 12 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 460 | 0.65 | 0.77 | 60 | empty |
| 2 | 71 | 0.40 | 0.80 | 19 | empty |
Interfaces
3 interfaces between chains.
- B–C · 504 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 424 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 169 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 modified (engineered).
Compared structures
- 7VSP · Crystal strcuture of the tandem B-Box domains of COL2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q96502 · AlphaFold monomer V2.0 prediction for zinc finger protein constans- like 2 (Q96502) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96502
- Elsewhere: RCSB PDB 7VSP · PDBe 7VSP · UniProt Q96502
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