MolNFT v1 · #189615 · protein
Structure of aminotransferase
7VNO · 454AA long hypothetical 4-aminobutyrate aminotransferase: “Structure of aminotransferase”. X-ray diffraction, 1 ligand (PLP), 6 pockets (best druggability 0.76). MolNFT v1 #189615 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7VNO
- Type
- protein
- Length
- 904 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 454AA long hypothetical 4-aminobutyrate aminotransferase
- UniProt
- O50131
- Ligands
- PLP
- Pockets
- 6 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 454AA long hypothetical 4-aminobutyrate aminotransferase | protein | 452 | 40% helix, 18% strand | O50131 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 3 copies · chains A, B
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 472 | 0.76 | 0.84 | 71 | PLP |
| 2 | 320 | 0.75 | 0.87 | 51 | PLP |
| 3 | 143 | 0.49 | 0.78 | 24 | empty |
| 4 | 73 | 0.32 | 0.74 | 17 | GOL |
| 5 | 61 | 0.31 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 5187 Ų buried · 84 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 cofactor (pyridoxal phosphate Schiff base).
Compared structures
- 7VNO · Structure of aminotransferase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O50131
- Elsewhere: RCSB PDB 7VNO · PDBe 7VNO · UniProt O50131
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.