MolNFT v1 · #189490 · protein

The crystal structure of L-leucine dehydrogenase from pseudomonas aeruginosa

7VID: “The crystal structure of L-leucine dehydrogenase from pseudomonas aeruginosa”. X-ray diffraction, 6 pockets (best druggability 0.74). MolNFT v1 #189490 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7VID
Type: protein
Length: 680 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Leucine dehydrogenase
UniProt: Q9HYI7
Pockets: 6 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 48% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Leucine dehydrogenase	protein	339	48% helix, 17% strand	Q9HYI7
B	Leucine dehydrogenase	protein	341	48% helix, 18% strand	Q9HYI7

Ligands and binding sites

GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	690	0.74	0.80	64	GOL
2	711	0.69	0.77	61	GOL
3	270	0.59	0.79	28	empty
4	241	0.57	0.78	32	empty
5	54	0.32	0.77	14	empty

Interfaces

1 interface between chains.

A–B · 1016 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

7VID · The crystal structure of L-leucine dehydrogenase from Pseudomonas aeruginosa · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HYI7
Elsewhere: RCSB PDB 7VID · PDBe 7VID · UniProt Q9HYI7

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