MolNFT v1 · #189469 · protein
Cryo-EM structure of machupo virus dimeric polymerase L
7VH2 · RNA-directed RNA polymerase L: “Cryo-EM structure of machupo virus dimeric polymerase L”. Electron microscopy, 20 pockets (best druggability 0.83). MolNFT v1 #189469 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7VH2
- Type
- protein
- Length
- 1,612 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase L
- EC
- 2.7.7.48, 3.1.-.-
- UniProt
- Q6IUF8
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 1 distinct chain · 41% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-directed RNA polymerase L (EC 2.7.7.48, 3.1.-.-) | protein | 1612 | 41% helix, 6% strand | Q6IUF8 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 903 | 0.83 | 0.85 | 85 | empty |
| 2 | 361 | 0.79 | 0.88 | 61 | empty |
| 3 | 592 | 0.79 | 0.84 | 51 | empty |
| 4 | 641 | 0.75 | 0.81 | 65 | empty |
| 5 | 644 | 0.70 | 0.78 | 84 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 7VH2 · Cryo-EM structure of Machupo virus dimeric polymerase L · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6IUF8
- Elsewhere: RCSB PDB 7VH2 · PDBe 7VH2 · UniProt Q6IUF8
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