MolNFT v1 · #189411 · protein

Crystal structure of nucleotide-free IRGB6

7VES · T-cell-specific guanine nucleotide triphosphate-binding…: “Crystal structure of nucleotide-free IRGB6”. X-ray diffraction, 6 pockets (best druggability 0.57). MolNFT v1 #189411 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7VES
Type: protein
Length: 367 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: T-cell-specific guanine nucleotide triphosphate-binding protein 2
EC: 3.6.5.-
UniProt: Q3T9E4
Pockets: 6 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 56% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	T-cell-specific guanine nucleotide triphosphate-binding protein 2 (EC 3.6.5.-)	protein	367	56% helix, 10% strand	Q3T9E4

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	166	0.57	0.81	21	empty
2	148	0.49	0.78	25	empty
3	59	0.45	0.82	12	empty
4	93	0.43	0.78	19	empty
5	53	0.37	0.80	16	empty

Compared structures

7VES · Crystal Structure of nucleotide-free Irgb6 · the same entry in another collection · chain A against A, TM-score 1.00
Q3T9E4 · AlphaFold monomer V2.0 prediction for T-cell-specific guanine nucleotide… · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q3T9E4
Elsewhere: RCSB PDB 7VES · PDBe 7VES · UniProt Q3T9E4

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