MolNFT v1 · #189299 · protein
Crystal structure of the dimeric ECHSP60
7V98 · 60 kda chaperonin: “Crystal structure of the dimeric ECHSP60”. X-ray diffraction, 10 pockets (best druggability 0.58). MolNFT v1 #189299 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7V98
- Type
- protein
- Length
- 772 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 60 kda chaperonin
- EC
- 5.6.1.7
- UniProt
- A0A097BVP4
- Pockets
- 10 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 60 kda chaperonin (EC 5.6.1.7) | protein | 386 | 55% helix, 17% strand | A0A097BVP4 |
| B | 60 kda chaperonin (EC 5.6.1.7) | protein | 386 | 53% helix, 18% strand | A0A097BVP4 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.58 | 0.86 | 24 | empty |
| 2 | 251 | 0.54 | 0.77 | 41 | empty |
| 3 | 256 | 0.53 | 0.76 | 38 | empty |
| 4 | 244 | 0.51 | 0.75 | 31 | empty |
| 5 | 190 | 0.47 | 0.75 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 2011 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 7V98 · Crystal Structure of the Dimeric EcHsp60 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A097BVP4
- Elsewhere: RCSB PDB 7V98 · PDBe 7V98 · UniProt A0A097BVP4
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