MolNFT v1 · #189280 · protein
Crystal structure of the pwwp-arid domain of ARID4A
7V8N · At-rich interactive domain-containing protein 4A: “Crystal structure of the pwwp-arid domain of ARID4A”. X-ray diffraction, 3 pockets (best druggability 0.63). MolNFT v1 #189280 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 7V8N
- Type
- protein
- Length
- 428 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- At-rich interactive domain-containing protein 4A
- UniProt
- P29374
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | At-rich interactive domain-containing protein 4A | protein | 220 | 45% helix, 14% strand | P29374 |
| B | At-rich interactive domain-containing protein 4A | protein | 208 | 45% helix, 15% strand | P29374 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 512 | 0.63 | 0.76 | 67 | empty |
| 2 | 133 | 0.42 | 0.75 | 24 | empty |
| 3 | 60 | 0.29 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 592 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 7V8N · Crystal structure of the PWWP-ARID domain of ARID4A · the same entry in another collection · chain A against A, TM-score 1.00
- P29374 · AlphaFold monomer V2.0 prediction for at-rich interactive domain- containing protein 4A… · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29374
- Elsewhere: RCSB PDB 7V8N · PDBe 7V8N · UniProt P29374
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