MolNFT v1 · #189221 · protein
Lccomt in complex with sah
7V6L: “Lccomt in complex with sah”. X-ray diffraction, 1 ligand (SAH), 11 pockets (best druggability 0.83). MolNFT v1 #189221 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7V6L
- Type
- protein
- Length
- 691 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lccomt
- Ligands
- SAH
- Pockets
- 11 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lccomt | protein | 344 | 49% helix, 17% strand | — |
| B | Lccomt | protein | 347 | 51% helix, 16% strand | — |
Ligands and binding sites
- SAH · S-adenosyl-L-homocysteine · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 284 | 0.83 | 0.93 | 52 | SAH |
| 2 | 857 | 0.79 | 0.81 | 70 | SAH |
| 3 | 169 | 0.57 | 0.81 | 18 | empty |
| 4 | 65 | 0.56 | 0.89 | 19 | empty |
| 5 | 115 | 0.41 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 4377 Ų buried · 49 hydrogen bonds · protein-protein
Compared structures
- 7V6L · LcCOMT in complex with SAH · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7V6L · PDBe 7V6L
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.