MolNFT v1 · #189163 · protein
Cryo-EM structure of camellia sinensis glutamine synthetase csgsib inactive pentamer state I
7V4J: “Cryo-EM structure of camellia sinensis glutamine synthetase csgsib inactive pentamer state I”. Electron microscopy, 13 pockets (best druggability 0.77). MolNFT v1 #189163 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7V4J
- Type
- protein
- Length
- 1,275 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamine synthetase
- EC
- 6.3.1.2
- UniProt
- Q762D2
- Pockets
- 13 · best druggability 0.77
Structure
electron microscopy · 1 distinct chain · 27% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Glutamine synthetase (EC 6.3.1.2) | protein | 255 | 27% helix, 22% strand | Q762D2 |
Pockets
13 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 556 | 0.77 | 0.83 | 78 | empty |
| 2 | 580 | 0.75 | 0.82 | 80 | empty |
| 3 | 592 | 0.73 | 0.80 | 65 | empty |
| 4 | 274 | 0.64 | 0.82 | 34 | empty |
| 5 | 260 | 0.62 | 0.80 | 34 | empty |
Interfaces
7 interfaces between chains.
- D–E · 1403 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 1378 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 1372 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 1324 Ų buried · 20 hydrogen bonds · protein-protein
- B–E · 1319 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 7V4J · Cryo-EM Structure of Camellia sinensis glutamine synthetase CsGSIb inactive Pentamer… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q762D2
- Elsewhere: RCSB PDB 7V4J · PDBe 7V4J · UniProt Q762D2
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