MolNFT v1 · #189140 · protein

Crystal structure of cmet in complex with a novel inhibitor

7V3S · Hepatocyte growth factor receptor: “Crystal structure of cmet in complex with a novel inhibitor”. X-ray diffraction, 1 ligand (5I9), 1 pocket (best druggability 0.73). MolNFT v1 #189140 on GenesisL1: 3D structure, binding sites and…

PDB: 7V3S
Type: protein
Length: 284 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hepatocyte growth factor receptor
EC: 2.7.10.1
UniProt: P08581
Ligands: 5I9
Pockets: 1 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hepatocyte growth factor receptor (EC 2.7.10.1)	protein	284	42% helix, 16% strand	P08581

Ligands and binding sites

5I9 · ~{N}1'-[3-fluoranyl-4-(10~{H}-pyrido[3,2-B][1, 4]benzoxazin-4-yloxy)phenyl]-~{N}1-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	429	0.73	0.83	58	5I9

Compared structures

7V3S · Crystal structure of CMET in complex with a novel inhibitor · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08581
Elsewhere: RCSB PDB 7V3S · PDBe 7V3S · UniProt P08581

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