MolNFT v1 · #189112 · protein

Crystal structure of juvenile hormone acid methyltransferase jhamt ISOFORM3 from silkworm

7V2S · METHYLTRANFER_DOM domain-containing protein: “Crystal structure of juvenile hormone acid methyltransferase jhamt ISOFORM3 from silkworm”. X-ray diffraction, 5 pockets (best druggability 0.81). MolNFT v1 #189112 on GenesisL1: 3D…

PDB: 7V2S
Type: protein
Length: 514 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: METHYLTRANFER_DOM domain-containing protein
UniProt: H9JLJ1
Pockets: 5 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	METHYLTRANFER_DOM domain-containing protein	protein	256	41% helix, 27% strand	H9JLJ1
B	METHYLTRANFER_DOM domain-containing protein	protein	258	39% helix, 26% strand	H9JLJ1

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	260	0.81	0.93	37	empty
2	340	0.70	0.83	35	empty
3	124	0.45	0.78	23	empty
4	84	0.44	0.80	15	empty
5	113	0.42	0.77	18	empty

Interfaces

1 interface between chains.

A–B · 1274 Å² buried · 26 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 18 modified (engineered).

Compared structures

7V2S · Crystal structure of juvenile hormone acid methyltransferase JHAMT isoform3 from silkworm · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt H9JLJ1
Elsewhere: RCSB PDB 7V2S · PDBe 7V2S · UniProt H9JLJ1

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