MolNFT v1 · #188994 · protein
GEA2 OPEN/OPEN conformation (composite structure)
7UTH · GEA2 isoform 1: “GEA2 OPEN/OPEN conformation (composite structure)”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #188994 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7UTH
- Type
- protein
- Length
- 2,242 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GEA2 isoform 1
- UniProt
- A0A8H8ULJ2
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 1 distinct chain · 65% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | GEA2 isoform 1 | protein | 1121 | 65% helix, 0% strand | A0A8H8ULJ2 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1025 | 0.81 | 0.82 | 101 | empty |
| 2 | 121 | 0.75 | 0.94 | 24 | empty |
| 3 | 274 | 0.74 | 0.87 | 41 | empty |
| 4 | 108 | 0.74 | 0.94 | 24 | empty |
| 5 | 122 | 0.74 | 0.93 | 30 | empty |
Interfaces
1 interface between chains.
- A–B · 2386 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 7UTH · Gea2 open/open conformation (composite structure) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A8H8ULJ2
- Elsewhere: RCSB PDB 7UTH · PDBe 7UTH · UniProt A0A8H8ULJ2
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