MolNFT v1 · #188849 · protein

Time-resolved structure of metallo beta-lactamase L1 in a complex with cleaved moxalactam (150 ms snapshot)

7UHM · Putative metallo-beta-lactamase L1 (beta-lactamase type II)…: “Time-resolved structure of metallo beta-lactamase L1 in a complex with cleaved moxalactam (150 ms snapshot)”. X-ray diffraction, 2 ligands (XQP, ZN), 1 pocket (best…

PDB: 7UHM
Type: protein
Length: 264 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative metallo-beta-lactamase L1 (beta-lactamase type II) (ec 3.5.2.6) (penicillinase)
EC: 3.5.2.6
UniProt: B2FTM1
Ligands: XQP, ZN
Pockets: 1 · best druggability 0.42

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative metallo-beta-lactamase L1 (beta-lactamase type II) (ec 3.5.2.6) (penicillinase) (EC 3.5.2.6)	protein	264	30% helix, 24% strand	B2FTM1

Ligands and binding sites

XQP · (2R)-2-[(R)-carboxy{[(2R)-2-carboxy-2-(4-hydroxyphenyl)acetyl]amino}methoxymethyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-oxazine-4-carboxylic acid · ligand · chains A
ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	114	0.42	0.76	25	ZN, XQP

Compared structures

7UHM · Time-Resolved Structure of Metallo Beta-Lactamase L1 in a Complex with Cleaved Moxalactam… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B2FTM1
Elsewhere: RCSB PDB 7UHM · PDBe 7UHM · UniProt B2FTM1

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