MolNFT v1 · #188841 · protein
TAF14 et domain in complex with C-terminal tail of TAF2
7UHE · Transcription initiation factor tfiid subunit 14: “TAF14 et domain in complex with C-terminal tail of TAF2”. X-ray diffraction, 1 pocket (best druggability 0.44). MolNFT v1 #188841 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7UHE
- Type
- protein
- Length
- 164 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription initiation factor tfiid subunit 14; C-terminal tail of transcription…
- UniProt
- P35189, P23255
- Pockets
- 1 · best druggability 0.44
Structure
x-ray diffraction · 4 distinct chains · 48% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription initiation factor tfiid subunit 14 | protein | 71 | 56% helix, 15% strand | P35189 |
| B | C-terminal tail of transcription initiation factor tfiid subunit 2 | protein | 9 | 0% helix, 56% strand | P23255 |
| C | Transcription initiation factor tfiid subunit 14 | protein | 74 | 53% helix, 18% strand | P35189 |
| D | C-terminal tail of transcription initiation factor tfiid subunit 2 | protein | 10 | 0% helix, 50% strand | P23255 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 111 | 0.44 | 0.78 | 27 | empty |
Interfaces
5 interfaces between chains.
- C–D · 689 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 566 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 554 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 242 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 140 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7UHE · Taf14 ET domain in complex with C-terminal tail of Taf2 · the same entry in another collection · chain D against D, TM-score 1.00
- P35189 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 14… · a predicted model of the same protein · chain A against A, TM-score 0.97
- P23255 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 2… · a predicted model of the same protein · chain B against A, TM-score 0.54
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35189
- Every structure of UniProt P23255
- Elsewhere: RCSB PDB 7UHE · PDBe 7UHE · UniProt P35189 · UniProt P23255
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