MolNFT v1 · #188735 · protein

VPS13 adaptor binding domain in complex with MCP1 pxp motif peptide

7U8T · MCP1 pxp MOTIF,PUTATIVE vacuolar protein sorting-associated…: “VPS13 adaptor binding domain in complex with MCP1 pxp motif peptide”. X-ray diffraction, 12 pockets (best druggability 0.72). MolNFT v1 #188735 on GenesisL1: 3D…

PDB: 7U8T
Type: protein
Length: 1,145 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MCP1 pxp MOTIF,PUTATIVE vacuolar protein sorting-associated protein
UniProt: G0S0T5, G0S3B8
Pockets: 12 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 3% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	MCP1 pxp MOTIF,PUTATIVE vacuolar protein sorting-associated protein	protein	540	3% helix, 49% strand	G0S0T5, G0S3B8
B	MCP1 pxp MOTIF,PUTATIVE vacuolar protein sorting-associated protein	protein	605	2% helix, 50% strand	G0S3B8

Pockets

12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	888	0.72	0.77	90	empty
2	61	0.61	0.92	23	empty
3	138	0.56	0.82	30	empty
4	149	0.50	0.78	22	empty
5	106	0.49	0.81	28	empty

Interfaces

1 interface between chains.

A–B · 1037 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

7U8T · Vps13 adaptor binding domain in complex with Mcp1 PxP motif peptide · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0S0T5
Every structure of UniProt G0S3B8
Elsewhere: RCSB PDB 7U8T · PDBe 7U8T · UniProt G0S0T5 · UniProt G0S3B8

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