MolNFT v1 · #188626 · protein
TMEM106B(120-254) T185S protofilament from frontotemporal lobar degeneration with tdp-43 pathology (ftld-tdp) type a (all cases combined).
7U18 · TMEM106B protein: “TMEM106B(120-254) T185S protofilament from frontotemporal lobar degeneration with tdp-43 pathology (ftld-tdp)…”. Electron microscopy, 1 ligand (NAG), 4 pockets (best druggability 0.53). MolNFT v1 #188626 on…
- PDB
- 7U18
- Type
- protein
- Length
- 405 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TMEM106B protein
- UniProt
- Q8N353
- Ligands
- NAG
- Pockets
- 4 · best druggability 0.53
Structure
electron microscopy · 1 distinct chain · 0% helix, 76% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | TMEM106B protein | protein | 135 | 0% helix, 76% strand | Q8N353 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 12 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 240 | 0.53 | 0.76 | 27 | empty |
| 2 | 113 | 0.53 | 0.82 | 22 | empty |
| 3 | 134 | 0.51 | 0.79 | 20 | empty |
| 4 | 213 | 0.46 | 0.74 | 36 | empty |
Interfaces
3 interfaces between chains.
- B–C · 5973 Ų buried · 191 hydrogen bonds · protein-protein
- A–B · 5971 Ų buried · 193 hydrogen bonds · protein-protein
- A–C · 82 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 glycan, 3 disulfide (N-glycosylation, disulfide).
Compared structures
- 7U18 · TMEM106B(120-254) T185S protofilament from frontotemporal lobar degeneration with TDP-43… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N353
- Elsewhere: RCSB PDB 7U18 · PDBe 7U18 · UniProt Q8N353
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.