MolNFT v1 · #188584 · protein
Cryo-EM structure of antibody TJ5-5 bound to H3 cobra TJ5 hemagglutinin
7TZ5 · TJ5-5 heavy chain: “Cryo-EM structure of antibody TJ5-5 bound to H3 cobra TJ5 hemagglutinin”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #188584 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7TZ5
- Type
- protein
- Length
- 2,142 residues
- Chains
- 9
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TJ5-5 heavy chain; TJ5-5 light chain; Hemagglutinin
- UniProt
- M1ND93
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 3 distinct chains · 15% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H, I, J | TJ5-5 heavy chain | protein | 123 | 0% helix, 29% strand | — |
| L, M, N | TJ5-5 light chain | protein | 108 | 0% helix, 32% strand | — |
| A, B, C | Hemagglutinin | protein | 483 | 22% helix, 29% strand | M1ND93 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1031 | 0.80 | 0.81 | 60 | empty |
| 2 | 859 | 0.73 | 0.77 | 72 | empty |
| 3 | 956 | 0.72 | 0.76 | 73 | empty |
| 4 | 121 | 0.72 | 0.92 | 27 | empty |
| 5 | 286 | 0.72 | 0.85 | 36 | empty |
Interfaces
12 interfaces between chains.
- A–C · 2160 Ų buried · 29 hydrogen bonds · protein-protein
- A–B · 2159 Ų buried · 31 hydrogen bonds · protein-protein
- B–C · 2140 Ų buried · 23 hydrogen bonds · protein-protein
- J–B · 944 Ų buried · 9 hydrogen bonds · protein-protein
- I–A · 939 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 disulfide (disulfide).
Compared structures
- 7TZ5 · Cryo-EM structure of antibody TJ5-5 bound to H3 COBRA TJ5 hemagglutinin · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt M1ND93
- Elsewhere: RCSB PDB 7TZ5 · PDBe 7TZ5 · UniProt M1ND93
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