MolNFT v1 · #188551 · protein + DNA
Cryo-EM of AFV6
7TXJ · DNA (5'-D(*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*A)-3'): “Cryo-EM of AFV6”. Electron microscopy, 5 pockets (best druggability 0.72). MolNFT v1 #188551 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7TXJ
- Type
- protein + DNA
- Length
- 376 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'-D(*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*A)-3'); MCP1; MCP2
- UniProt
- A7WKI9, A7WKJ0
- Pockets
- 5 · best druggability 0.72
Structure
electron microscopy · 3 distinct chains · 62% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1, 2 | DNA (5'-D(*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*A)-3') | dna | 12 | — | — |
| A | MCP1 | protein | 153 | 63% helix, 7% strand | A7WKI9 |
| a | MCP2 | protein | 199 | 62% helix, 0% strand | A7WKJ0 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1175 | 0.72 | 0.76 | 54 | empty |
| 2 | 116 | 0.57 | 0.84 | 23 | empty |
| 3 | 166 | 0.50 | 0.78 | 31 | empty |
| 4 | 228 | 0.50 | 0.75 | 21 | empty |
| 5 | 63 | 0.36 | 0.78 | 8 | empty |
Interfaces
6 interfaces between chains.
- A–a · 677 Ų buried · 3 hydrogen bonds · protein-protein
- 2–A · 627 Ų buried · 7 hydrogen bonds · protein-nucleic
- 1–A · 610 Ų buried · 6 hydrogen bonds · protein-nucleic
- 2–a · 483 Ų buried · 3 hydrogen bonds · protein-nucleic
- 1–2 · 471 Ų buried · 23 hydrogen bonds · nucleic-nucleic
Compared structures
- 7TXJ · Cryo-EM of AFV6 · the same entry in another collection · chain 1 against 1, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A7WKI9
- Every structure of UniProt A7WKJ0
- Elsewhere: RCSB PDB 7TXJ · PDBe 7TXJ · UniProt A7WKI9 · UniProt A7WKJ0
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