MolNFT v1 · #18851 · protein
Mouse importin alpha: non-phosphorylated SV40 cn peptide complex
1Q1T · Large T antigen: “Mouse importin alpha: non-phosphorylated SV40 cn peptide complex”. X-ray diffraction, 2 pockets (best druggability 0.45). MolNFT v1 #18851 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1Q1T
- Type
- protein
- Length
- 446 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Large T antigen; Importin alpha-2 subunit
- UniProt
- P03070
- Pockets
- 2 · best druggability 0.45
Structure
x-ray diffraction · 3 distinct chains · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Large T antigen | protein | 8 | 0% helix, 0% strand | P03070 |
| B | Large T antigen | protein | 11 | 0% helix, 0% strand | P03070 |
| C | Importin alpha-2 subunit | protein | 427 | 73% helix, 0% strand | P03070 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 63 | 0.45 | 0.82 | 13 | empty |
| 2 | 52 | 0.28 | 0.75 | 12 | empty |
Interfaces
2 interfaces between chains.
- B–C · 805 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 641 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 1Q1T · Mouse Importin alpha: non-phosphorylated SV40 CN peptide complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03070
- Elsewhere: RCSB PDB 1Q1T · PDBe 1Q1T · UniProt P03070
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