MolNFT v1 · #188474 · protein

Stable-5-lox elongated HA2 (4 copies asu)

7TTL · Arachidonate 5-lipoxygenase: “Stable-5-lox elongated HA2 (4 copies asu)”. X-ray diffraction, 1 ligand (FE2), 20 pockets (best druggability 0.86). MolNFT v1 #188474 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7TTL
Type: protein
Length: 2,607 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Arachidonate 5-lipoxygenase
EC: 1.13.11.34
UniProt: P09917
Ligands: FE2
Pockets: 20 · best druggability 0.86

Structure

x-ray diffraction · 4 distinct chains · 44% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Arachidonate 5-lipoxygenase (EC 1.13.11.34)	protein	674	44% helix, 13% strand	P09917
C	Arachidonate 5-lipoxygenase (EC 1.13.11.34)	protein	617	44% helix, 15% strand	P09917
D	Arachidonate 5-lipoxygenase (EC 1.13.11.34)	protein	673	44% helix, 14% strand	P09917
B	Arachidonate 5-lipoxygenase (EC 1.13.11.34)	protein	643	46% helix, 14% strand	P09917

Ligands and binding sites

FE2 · Fe (II) ion · metal · 4 copies · chains A, C, D, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1019	0.86	0.87	104	empty
2	1082	0.86	0.86	101	empty
3	859	0.81	0.83	101	empty
4	142	0.80	0.97	36	empty
5	111	0.80	0.98	29	empty

Interfaces

4 interfaces between chains.

D–B · 1118 Å² buried · 13 hydrogen bonds · protein-protein
A–C · 1062 Å² buried · 14 hydrogen bonds · protein-protein
A–B · 838 Å² buried · 10 hydrogen bonds · protein-protein
C–D · 197 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

7TTL · Stable-5-LOX elongated Ha2 (4 copies ASU) · the same entry in another collection · chain B against B, TM-score 1.00
P09917 · AlphaFold monomer V2.0 prediction for polyunsaturated fatty acid 5-lipoxygenase (P09917) · a predicted model of the same protein · chain C against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09917
Elsewhere: RCSB PDB 7TTL · PDBe 7TTL · UniProt P09917

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.