MolNFT v1 · #188386 · protein
P120RASGAP SH3 domain in complex with DLC1 rhogap domain
7TPB · RAS GTPase-activating protein 1: “P120RASGAP SH3 domain in complex with DLC1 rhogap domain”. X-ray diffraction, 20 pockets (best druggability 0.77). MolNFT v1 #188386 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7TPB
- Type
- protein
- Length
- 1,010 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAS GTPase-activating protein 1; Rho GTPase-activating protein 7
- UniProt
- B4DTL8
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 5 distinct chains · 55% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS GTPase-activating protein 1 | protein | 58 | 10% helix, 50% strand | B4DTL8 |
| B | Rho GTPase-activating protein 7 | protein | 194 | 64% helix, 0% strand | — |
| C, E, G | RAS GTPase-activating protein 1 | protein | 59 | 10% helix, 49% strand | B4DTL8 |
| D | Rho GTPase-activating protein 7 | protein | 195 | 64% helix, 0% strand | — |
| F, H | Rho GTPase-activating protein 7 | protein | 193 | 65% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 772 | 0.77 | 0.81 | 60 | empty |
| 2 | 773 | 0.72 | 0.78 | 84 | empty |
| 3 | 417 | 0.65 | 0.79 | 44 | empty |
| 4 | 230 | 0.62 | 0.82 | 42 | empty |
| 5 | 167 | 0.49 | 0.77 | 24 | empty |
Interfaces
10 interfaces between chains.
- E–F · 864 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 857 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 843 Ų buried · 11 hydrogen bonds · protein-protein
- G–H · 836 Ų buried · 9 hydrogen bonds · protein-protein
- F–H · 633 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7TPB · p120RasGAP SH3 domain in complex with DLC1 RhoGAP domain · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B4DTL8
- Elsewhere: RCSB PDB 7TPB · PDBe 7TPB · UniProt B4DTL8
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