MolNFT v1 · #18832 · protein
Crystal structure of E.COLI glucokinase (glk)
1Q18: “Crystal structure of E.COLI glucokinase (glk)”. X-ray diffraction, 6 pockets (best druggability 0.82). MolNFT v1 #18832 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1Q18
- Type
- protein
- Length
- 640 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucokinase
- EC
- 2.7.1.2
- UniProt
- P0A6V8
- Pockets
- 6 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Glucokinase (EC 2.7.1.2) | protein | 320 | 43% helix, 22% strand | P0A6V8 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 162 | 0.82 | 0.97 | 30 | empty |
| 2 | 794 | 0.71 | 0.77 | 73 | empty |
| 3 | 593 | 0.64 | 0.75 | 67 | empty |
| 4 | 101 | 0.43 | 0.78 | 18 | empty |
| 5 | 93 | 0.42 | 0.78 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1649 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6V8
- Elsewhere: RCSB PDB 1Q18 · PDBe 1Q18 · UniProt P0A6V8
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