MolNFT v1 · #188144 · protein + DNA

Structure of FOXP3-DNA complex

7TDW · Forkhead box P3: “Structure of FOXP3-DNA complex”. X-ray diffraction, 4 pockets (best druggability 0.53). MolNFT v1 #188144 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7TDW
Type: protein + DNA
Length: 118 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Forkhead box P3; DNA (5'-D(*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*AP*CP*TP*C)-3'); DNA…
UniProt: Q53Z59
Pockets: 4 · best druggability 0.53

Structure

x-ray diffraction · 3 distinct chains · 43% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Forkhead box P3	protein	90	43% helix, 12% strand	Q53Z59
B	DNA (5'-D(APAPAPTPTPTPGPTPTPTPAPCPTPC)-3')	dna	14	—	—
C	DNA (5'-D(PGPAPGPTPAPAPAPCPAPAPAPTPTPT)-3')	dna	14	—	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	90	0.53	0.84	20	empty
2	54	0.40	0.81	14	empty
3	78	0.34	0.76	15	empty
4	53	0.24	0.73	17	empty

Interfaces

3 interfaces between chains.

B–C · 614 Å² buried · 45 hydrogen bonds · nucleic-nucleic
A–C · 426 Å² buried · 8 hydrogen bonds · protein-nucleic
A–B · 407 Å² buried · 2 hydrogen bonds · protein-nucleic

Compared structures

7TDW · Structure of FOXP3-DNA complex · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q53Z59
Elsewhere: RCSB PDB 7TDW · PDBe 7TDW · UniProt Q53Z59

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