MolNFT v1 · #188139 · protein
Cryo-EM structure of transmembrane aaa+ protease ftsh in the ADP state
7TDO · ATP-dependent zinc metalloprotease ftsh: “Cryo-EM structure of transmembrane aaa+ protease ftsh in the ADP state”. Electron microscopy, 1 ligand (ADP), 20 pockets (best druggability 0.75). MolNFT v1 #188139 on GenesisL1: 3D…
- PDB
- 7TDO
- Type
- protein
- Length
- 2,520 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent zinc metalloprotease ftsh
- EC
- 3.4.24.-
- UniProt
- Q9WZ49
- Ligands
- ADP
- Pockets
- 20 · best druggability 0.75
Structure
electron microscopy · 1 distinct chain · 42% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | ATP-dependent zinc metalloprotease ftsh (EC 3.4.24.-) | protein | 420 | 42% helix, 10% strand | Q9WZ49 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 6 copies · chains A, B, C, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1041 | 0.75 | 0.78 | 104 | empty |
| 2 | 1041 | 0.75 | 0.78 | 102 | ADP |
| 3 | 950 | 0.74 | 0.78 | 109 | empty |
| 4 | 1099 | 0.74 | 0.77 | 106 | ADP |
| 5 | 816 | 0.73 | 0.78 | 93 | empty |
Interfaces
6 interfaces between chains.
- D–F · 2125 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 2076 Ų buried · 21 hydrogen bonds · protein-protein
- A–E · 1994 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 1983 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 1980 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 7TDO · Cryo-EM structure of transmembrane AAA+ protease FtsH in the ADP state · the same entry in another collection · chain F against F, TM-score 1.00
- Q9WZ49 · AlphaFold monomer V2.0 prediction for ATP-dependent zinc metalloprotease ftsh (Q9WZ49) · a predicted model of the same protein · chain C against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WZ49
- Elsewhere: RCSB PDB 7TDO · PDBe 7TDO · UniProt Q9WZ49
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