MolNFT v1 · #188062 · protein
Trimer-to-monomer disruption of tumor necrosis factor-alpha (TNF- alpha) by unnatural ALPHA/BETA-peptide-1
7TA6: “Trimer-to-monomer disruption of tumor necrosis factor-alpha (TNF- alpha) by unnatural ALPHA/BETA-peptide-1”. X-ray diffraction, 2 ligands (K, NH2). MolNFT v1 #188062 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7TA6
- Type
- protein
- Length
- 1,328 residues
- Chains
- 16
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P01375
- Ligands
- K, NH2
Structure
x-ray diffraction · 9 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 141 | — | P01375 |
| B | — | protein | 129 | — | P01375 |
| C | — | protein | 138 | — | P01375 |
| D | — | protein | 145 | — | P01375 |
| E | — | protein | 136 | — | P01375 |
| F | — | protein | 138 | — | P01375 |
| G | — | protein | 138 | — | P01375 |
| H | — | protein | 131 | — | P01375 |
| I, J, K, L, M, N, O, P | — | protein | 29 | — | — |
Ligands and binding sites
- K · Potassium ion · metal · chains H
- NH2 · Amino group · ion · 8 copies · chains I, P, J, K, O, M, N, L
- EDO · 1,2-ethanediol · additive · 8 copies · chains A, N, B, I, J, C, E, D, K, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7TA6 · Trimer-to-Monomer Disruption of Tumor Necrosis Factor-alpha (TNF-alpha) by unnatural… · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01375
- Elsewhere: RCSB PDB 7TA6 · PDBe 7TA6 · UniProt P01375
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