MolNFT v1 · #188055 · protein
Human ornithine aminotransferase (hoat) crystallized at pH 6.0
7T9Z · Ornithine aminotransferase, mitochondrial: “Human ornithine aminotransferase (hoat) crystallized at pH 6.0”. X-ray diffraction, 1 ligand (PLP), 9 pockets (best druggability 0.76). MolNFT v1 #188055 on GenesisL1: 3D structure…
- PDB
- 7T9Z
- Type
- protein
- Length
- 1,206 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ornithine aminotransferase, mitochondrial
- EC
- 2.6.1.13
- UniProt
- P04181
- Ligands
- PLP
- Pockets
- 9 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) | protein | 402 | 39% helix, 18% strand | P04181 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 361 | 0.76 | 0.86 | 62 | PLP |
| 2 | 101 | 0.76 | 0.97 | 33 | PLP |
| 3 | 718 | 0.72 | 0.79 | 54 | empty |
| 4 | 329 | 0.64 | 0.80 | 39 | empty |
| 5 | 485 | 0.64 | 0.76 | 59 | PLP |
Interfaces
3 interfaces between chains.
- B–C · 5256 Ų buried · 79 hydrogen bonds · protein-protein
- A–B · 711 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 189 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 cofactor (pyridoxal phosphate Schiff base).
Compared structures
- 7T9Z · Human Ornithine Aminotransferase (hOAT) crystallized at pH 6.0 · the same entry in another collection · chain A against A, TM-score 1.00
- P04181 · AlphaFold monomer V2.0 prediction for ornithine aminotransferase, mitochondrial (P04181) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04181
- Elsewhere: RCSB PDB 7T9Z · PDBe 7T9Z · UniProt P04181
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