MolNFT v1 · #188035 · protein
Brxr from acinetobacter brex type I phage restriction system
7T8L: “Brxr from acinetobacter brex type I phage restriction system”. X-ray diffraction, 1 ligand (CL), 7 pockets (best druggability 0.85). MolNFT v1 #188035 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7T8L
- Type
- protein
- Length
- 558 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Brxr
- UniProt
- A0A7H8SL41
- Ligands
- CL
- Pockets
- 7 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Brxr | protein | 284 | 38% helix, 27% strand | A0A7H8SL41 |
| B | Brxr | protein | 274 | 37% helix, 26% strand | A0A7H8SL41 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 609 | 0.85 | 0.90 | 57 | empty |
| 2 | 828 | 0.78 | 0.81 | 72 | EDO |
| 3 | 84 | 0.52 | 0.84 | 21 | EDO |
| 4 | 81 | 0.35 | 0.75 | 14 | empty |
| 5 | 70 | 0.31 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 4407 Ų buried · 55 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 modified (engineered, oxidation).
Compared structures
- 7T8L · BrxR from Acinetobacter BREX type I phage restriction system · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A7H8SL41
- Elsewhere: RCSB PDB 7T8L · PDBe 7T8L · UniProt A0A7H8SL41
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