MolNFT v1 · #187954 · protein

Structure of dimeric unphosphorylated pediculus humanus (pH) PINK1 D357A mutant

7T4N · SERINE/THREONINE-protein kinase PINK1, putative: “Structure of dimeric unphosphorylated pediculus humanus (pH) PINK1 D357A mutant”. Electron microscopy, 10 pockets (best druggability 0.79). MolNFT v1 #187954 on GenesisL1: 3D…

PDB: 7T4N
Type: protein
Length: 803 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase PINK1, putative
EC: 2.7.11.1
UniProt: E0W1I1
Pockets: 10 · best druggability 0.79

Structure

electron microscopy · 2 distinct chains · 38% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase PINK1, putative (EC 2.7.11.1)	protein	404	38% helix, 16% strand	E0W1I1
B	SERINE/THREONINE-protein kinase PINK1, putative (EC 2.7.11.1)	protein	399	38% helix, 16% strand	E0W1I1

Pockets

10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	939	0.79	0.81	80	empty
2	491	0.79	0.86	58	empty
3	671	0.76	0.81	67	empty
4	84	0.41	0.79	16	empty
5	87	0.39	0.77	15	empty

Interfaces

1 interface between chains.

A–B · 1771 Å² buried · 42 hydrogen bonds · protein-protein

Compared structures

7T4N · Structure of dimeric unphosphorylated Pediculus humanus (Ph) PINK1 D357A mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E0W1I1
Elsewhere: RCSB PDB 7T4N · PDBe 7T4N · UniProt E0W1I1

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