MolNFT v1 · #187951 · protein
Structure of dimeric phosphorylated pediculus humanus (pH) PINK1 with kinked alpha-C helix in chain B
7T4K · SERINE/THREONINE-protein kinase PINK1, putative: “Structure of dimeric phosphorylated pediculus humanus (pH) PINK1 with kinked alpha-C helix in chain B”. Electron microscopy, 10 pockets (best druggability 0.78). MolNFT v1 #187951 on…
- PDB
- 7T4K
- Type
- protein
- Length
- 782 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase PINK1, putative
- EC
- 2.7.11.1
- UniProt
- E0W1I1
- Pockets
- 10 · best druggability 0.78
Structure
electron microscopy · 2 distinct chains · 37% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase PINK1, putative (EC 2.7.11.1) | protein | 379 | 38% helix, 16% strand | E0W1I1 |
| B | SERINE/THREONINE-protein kinase PINK1, putative (EC 2.7.11.1) | protein | 403 | 37% helix, 15% strand | E0W1I1 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 468 | 0.78 | 0.86 | 66 | empty |
| 2 | 128 | 0.62 | 0.86 | 26 | empty |
| 3 | 113 | 0.62 | 0.87 | 23 | empty |
| 4 | 120 | 0.60 | 0.86 | 27 | empty |
| 5 | 88 | 0.41 | 0.78 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1470 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 7T4K · Structure of dimeric phosphorylated Pediculus humanus (Ph) PINK1 with kinked alpha-C… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E0W1I1
- Elsewhere: RCSB PDB 7T4K · PDBe 7T4K · UniProt E0W1I1
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