MolNFT v1 · #187789 · protein

KIRBAC1.1 mutant - I131C

7SWJ · Inward rectifier potassium channel: “KIRBAC1.1 mutant - I131C”. Solid-state nmr, 20 pockets (best druggability 0.88). MolNFT v1 #187789 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7SWJ
Type: protein
Length: 1,204 residues
Chains: 4
Method: solid-state nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inward rectifier potassium channel
UniProt: P83698
Pockets: 20 · best druggability 0.88

Structure

solid-state nmr · 1 distinct chain · 38% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Inward rectifier potassium channel	protein	301	38% helix, 16% strand	P83698

Pockets

20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1128	0.88	0.90	132	empty
2	744	0.86	0.88	53	empty
3	1157	0.82	0.83	112	empty
4	1091	0.81	0.82	107	empty
5	849	0.80	0.83	83	empty

Interfaces

6 interfaces between chains.

B–C · 2691 Å² buried · 23 hydrogen bonds · protein-protein
A–B · 2691 Å² buried · 23 hydrogen bonds · protein-protein
C–D · 2688 Å² buried · 23 hydrogen bonds · protein-protein
A–D · 2686 Å² buried · 23 hydrogen bonds · protein-protein
B–D · 22 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7SWJ · KirBac1.1 mutant - I131C · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P83698
Elsewhere: RCSB PDB 7SWJ · PDBe 7SWJ · UniProt P83698

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