MolNFT v1 · #187754 · protein
Crystal structure of the wd-repeat domain of human SEC31A
7SUL · Protein transport protein SEC31A: “Crystal structure of the wd-repeat domain of human SEC31A”. X-ray diffraction, 10 pockets (best druggability 0.85). MolNFT v1 #187754 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7SUL
- Type
- protein
- Length
- 1,330 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein transport protein SEC31A
- UniProt
- O94979
- Pockets
- 10 · best druggability 0.85
Structure
x-ray diffraction · 4 distinct chains · 2% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein transport protein SEC31A | protein | 334 | 2% helix, 43% strand | O94979 |
| B | Protein transport protein SEC31A | protein | 335 | 3% helix, 43% strand | O94979 |
| C | Protein transport protein SEC31A | protein | 336 | 2% helix, 44% strand | O94979 |
| D | Protein transport protein SEC31A | protein | 325 | 3% helix, 47% strand | O94979 |
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1043 | 0.85 | 0.86 | 91 | empty |
| 2 | 778 | 0.81 | 0.84 | 61 | empty |
| 3 | 1041 | 0.81 | 0.82 | 74 | empty |
| 4 | 694 | 0.81 | 0.85 | 56 | empty |
| 5 | 497 | 0.74 | 0.83 | 58 | empty |
Interfaces
5 interfaces between chains.
- A–B · 625 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 467 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 220 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 85 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 46 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7SUL · Crystal structure of the WD-repeat domain of human SEC31A · the same entry in another collection · chain D against D, TM-score 1.00
- O94979 · AlphaFold monomer V2.0 prediction for protein transport protein SEC31A (O94979) · a predicted model of the same protein · chain D against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O94979
- Elsewhere: RCSB PDB 7SUL · PDBe 7SUL · UniProt O94979
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