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MolNFT v1 · #187703 · protein + DNA

Human endogenous retrovirus (herv-K) reverse transcriptase ternary complex with dsdna template primer and dntp

7SR6: “Human endogenous retrovirus (herv-K) reverse transcriptase ternary complex with dsdna template primer and dntp”. X-ray diffraction, 5 ligands (DCP, TTP, K). MolNFT v1 #187703 on GenesisL1: 3D structure, binding sites and pockets in…

PDB
7SR6
Type
protein + DNA
Length
2,082 residues
Chains
8
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
V9H0F6
Ligands
DCP, TTP, K, MG, CL

Structure

x-ray diffraction · 6 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A, F—protein566—V9H0F6
B, G—protein432—V9H0F6
D—dna23——
E—dna20——
H—dna23——
I—dna20——

Ligands and binding sites

  • DCP · 2'-deoxycytidine-5'-triphosphate · ligand · chains A, D, E
  • TTP · Thymidine-5'-triphosphate · ligand · chains F, H, I
  • K · Potassium ion · metal · 11 copies · chains A, B, D, F, H, G
  • MG · Magnesium ion · metal · 5 copies · chains A, D, F, G
  • CL · Chloride ion · ion · 2 copies · chains G
  • DIO · 1,4-diethylene dioxide · additive · 34 copies · chains A, B, F, G, H
  • EDO · 1,2-ethanediol · additive · 7 copies · chains A, B, F, G
  • PG6 · 1-(2-methoxy-ethoxy)-2-{2-[2-(2-methoxy-ethoxy]-ethoxy}-ethane · additive · 2 copies · chains B, G

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 7SR6 · Human Endogenous Retrovirus (HERV-K) reverse transcriptase ternary complex with dsDNA… · the same entry in another collection · chain B against B, TM-score 1.00

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