MolNFT v1 · #187654 · protein + RNA

RNA-induced tau amyloid fibril

7SP1 · Isoform tau-F of microtubule-associated protein tau: “RNA-induced tau amyloid fibril”. Electron microscopy, 2 pockets (best druggability 0.57). MolNFT v1 #187654 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7SP1
Type: protein + RNA
Length: 558 residues
Chains: 17
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isoform tau-F of microtubule-associated protein tau; RNA…
Pockets: 2 · best druggability 0.57

Structure

electron microscopy · 2 distinct chains · 0% helix, 56% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O	Isoform tau-F of microtubule-associated protein tau	protein	36	0% helix, 56% strand	—
P, Q	RNA (5'-R(APAPAPAPAPAPAPAPAPA)-3')	rna	9	—	—

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	285	0.57	0.77	38	empty
2	254	0.56	0.78	40	empty

Interfaces

54 interfaces between chains.

A–D · 1472 Å² buried · 47 hydrogen bonds · protein-protein
K–M · 1465 Å² buried · 42 hydrogen bonds · protein-protein
E–I · 1462 Å² buried · 42 hydrogen bonds · protein-protein
H–K · 1459 Å² buried · 42 hydrogen bonds · protein-protein
M–O · 1457 Å² buried · 43 hydrogen bonds · protein-protein

Compared structures

7SP1 · RNA-induced tau amyloid fibril · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7SP1 · PDBe 7SP1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.