MolNFT v1 · #187588 · protein

Cryoem structure of SGLT1 at 3.15 ångström resolution

7SLA · SODIUM/GLUCOSE cotransporter 1: “Cryoem structure of SGLT1 at 3.15 ångström resolution”. Electron microscopy, 1 ligand (Y01), 9 pockets (best druggability 0.82). MolNFT v1 #187588 on GenesisL1: 3D structure, binding sites and…

PDB: 7SLA
Type: protein
Length: 702 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SODIUM/GLUCOSE cotransporter 1; Nanobody NB1
Ligands: Y01
Pockets: 9 · best druggability 0.82

Structure

electron microscopy · 2 distinct chains · 53% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SODIUM/GLUCOSE cotransporter 1	protein	585	63% helix, 1% strand	—
B	Nanobody NB1	protein	117	0% helix, 36% strand	—

Ligands and binding sites

Y01 · Cholesterol hemisuccinate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	528	0.82	0.88	64	empty
2	156	0.70	0.89	25	empty
3	629	0.66	0.76	59	empty
4	157	0.57	0.81	20	empty
5	78	0.54	0.85	15	empty

Interfaces

1 interface between chains.

A–B · 765 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

7SLA · CryoEM structure of SGLT1 at 3.15 Angstrom resolution · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7SLA · PDBe 7SLA

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