MolNFT v1 · #187587 · protein
Cryoem structure of SMCT1
7SL9 · Sodium-coupled monocarboxylate transporter 1: “Cryoem structure of SMCT1”. Electron microscopy, 1 ligand (BUA), 5 pockets (best druggability 0.78). MolNFT v1 #187587 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7SL9
- Type
- protein
- Length
- 619 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sodium-coupled monocarboxylate transporter 1; Nanobody NB2
- UniProt
- Q8N695
- Ligands
- BUA
- Pockets
- 5 · best druggability 0.78
Structure
electron microscopy · 2 distinct chains · 55% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sodium-coupled monocarboxylate transporter 1 | protein | 497 | 68% helix, 0% strand | Q8N695 |
| B | Nanobody NB2 | protein | 122 | 2% helix, 33% strand | — |
Ligands and binding sites
- BUA · butanoic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 443 | 0.78 | 0.86 | 72 | BUA |
| 2 | 266 | 0.55 | 0.77 | 25 | empty |
| 3 | 67 | 0.35 | 0.76 | 14 | empty |
| 4 | 65 | 0.35 | 0.75 | 13 | empty |
| 5 | 64 | 0.34 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 924 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N695
- Elsewhere: RCSB PDB 7SL9 · PDBe 7SL9 · UniProt Q8N695
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