MolNFT v1 · #187509 · protein
Structure of xenopus laevis CRL2LRR1 (state 2)
7SHL · CULLIN_2 domain-containing protein: “Structure of xenopus laevis CRL2LRR1 (state 2)”. Electron microscopy, 1 ligand (ZN), 12 pockets (best druggability 0.78). MolNFT v1 #187509 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 7SHL
- Type
- protein
- Length
- 1,138 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CULLIN_2 domain-containing protein; TCEB2-prov protein; Elongin-C; LRR1; Ring-type…
- UniProt
- A0A1L8FVB6, Q6PHL7, Q6PHW7, A4QNS4, A0A1L8GNG7
- Ligands
- ZN
- Pockets
- 12 · best druggability 0.78
Structure
electron microscopy · 5 distinct chains · 47% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CULLIN_2 domain-containing protein | protein | 645 | 65% helix, 5% strand | A0A1L8FVB6 |
| B | TCEB2-prov protein | protein | 97 | 12% helix, 29% strand | Q6PHL7 |
| C | Elongin-C | protein | 98 | 39% helix, 13% strand | Q6PHW7 |
| L | LRR1 | protein | 282 | 22% helix, 20% strand | A4QNS4 |
| R | Ring-type domain-containing protein | protein | 16 | 0% helix, 69% strand | A0A1L8GNG7 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 127 | 0.78 | 0.95 | 26 | empty |
| 2 | 613 | 0.71 | 0.79 | 81 | empty |
| 3 | 148 | 0.63 | 0.85 | 25 | empty |
| 4 | 198 | 0.52 | 0.77 | 29 | empty |
| 5 | 63 | 0.48 | 0.84 | 14 | empty |
Interfaces
5 interfaces between chains.
- A–R · 1664 Ų buried · 37 hydrogen bonds · protein-protein
- B–C · 1050 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 1006 Ų buried · 10 hydrogen bonds · protein-protein
- A–L · 985 Ų buried · 7 hydrogen bonds · protein-protein
- C–L · 831 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7SHL · Structure of Xenopus laevis CRL2Lrr1 (State 2) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1L8FVB6
- Every structure of UniProt Q6PHL7
- Every structure of UniProt Q6PHW7
- Every structure of UniProt A4QNS4
- Every structure of UniProt A0A1L8GNG7
- Elsewhere: RCSB PDB 7SHL · PDBe 7SHL · UniProt A0A1L8FVB6 · UniProt Q6PHL7 · UniProt Q6PHW7 · UniProt A4QNS4 · UniProt A0A1L8GNG7
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