MolNFT v1 · #187501 · protein

Crystal structure of a VIRB8-like protein of type IV secretion system from rickettsia typhi in complex with a synthetic VIRB8 miniprotein binder

7SH3: “Crystal structure of a VIRB8-like protein of type IV secretion system from rickettsia typhi in complex with a…”. X-ray diffraction, 1 pocket (best druggability 0.54). MolNFT v1 #187501 on GenesisL1: 3D structure, binding sites and…

PDB: 7SH3
Type: protein
Length: 188 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Synthetic VIRB8 miniprotein binder; VIRB8-like protein of type IV secretion system
UniProt: Q68X84
Pockets: 1 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 53% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Synthetic VIRB8 miniprotein binder	protein	63	86% helix, 0% strand	—
B	VIRB8-like protein of type IV secretion system	protein	125	37% helix, 39% strand	Q68X84

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	102	0.54	0.83	19	empty

Interfaces

1 interface between chains.

A–B · 759 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

7SH3 · Crystal Structure of a VirB8-like Protein of Type IV Secretion System from Rickettsia… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q68X84
Elsewhere: RCSB PDB 7SH3 · PDBe 7SH3 · UniProt Q68X84

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