MolNFT v1 · #187483 · protein

Structure of pfcsp peptide 21 with antibody CIS43_VAR2

7SG5 · CIS43_VAR2 Fab heavy chain: “Structure of pfcsp peptide 21 with antibody CIS43_VAR2”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.64). MolNFT v1 #187483 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 7SG5
Type: protein
Length: 451 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CIS43_VAR2 Fab heavy chain; CIS43_VAR2 Fab light chain; Pfcsp peptide 21
Ligands: SO4
Pockets: 2 · best druggability 0.64

Structure

x-ray diffraction · 3 distinct chains · 7% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	CIS43_VAR2 Fab heavy chain	protein	221	8% helix, 52% strand	—
L	CIS43_VAR2 Fab light chain	protein	217	6% helix, 53% strand	—
A	Pfcsp peptide 21	protein	13	0% helix, 8% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · 5 copies · chains H, L
GOL · Glycerol · additive · chains H, L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	638	0.64	0.75	63	empty
2	72	0.29	0.73	22	empty

Interfaces

3 interfaces between chains.

H–L · 1882 Å² buried · 15 hydrogen bonds · protein-protein
H–A · 454 Å² buried · 14 hydrogen bonds · protein-protein
L–A · 415 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7SG5 · Structure of PfCSP peptide 21 with antibody CIS43_Var2 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7SG5 · PDBe 7SG5

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