MolNFT v1 · #187444 · protein

Crystal structure of Fab containing a fluorescent noncanonical amino acid with blocked excited state proton transfer

7SEN · 5C8* Fab heavy chain: “Crystal structure of Fab containing a fluorescent noncanonical amino acid with blocked excited state proton…”. X-ray diffraction, 3 pockets (best druggability 0.64). MolNFT v1 #187444 on GenesisL1: 3D…

PDB: 7SEN
Type: protein
Length: 436 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5C8* Fab heavy chain; 5C8* Fab light chain
Pockets: 3 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	5C8* Fab heavy chain	protein	221	10% helix, 49% strand	—
L	5C8* Fab light chain	protein	215	6% helix, 52% strand	—

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	649	0.64	0.75	64	empty
2	79	0.29	0.72	19	empty
3	56	0.27	0.73	14	empty

Interfaces

1 interface between chains.

H–L · 1814 Å² buried · 19 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide, 2 modified (disulfide, cyclization, nonstandard).

Compared structures

7SEN · Crystal structure of Fab containing a fluorescent noncanonical amino acid with blocked… · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 7SEN · PDBe 7SEN

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.