MolNFT v1 · #187387 · protein
Human glutaminase C (Y466W) with L-gln, open conformation
7SBM · Isoform 3 of glutaminase kidney isoform, mitochondrial: “Human glutaminase C (Y466W) with L-gln, open conformation”. X-ray diffraction, 1 ligand (GLN), 13 pockets (best druggability 0.74). MolNFT v1 #187387 on GenesisL1: 3D…
- PDB
- 7SBM
- Type
- protein
- Length
- 1,594 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform 3 of glutaminase kidney isoform, mitochondrial
- EC
- 3.5.1.2
- UniProt
- O94925
- Ligands
- GLN
- Pockets
- 13 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 48% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform 3 of glutaminase kidney isoform, mitochondrial (EC 3.5.1.2) | protein | 400 | 48% helix, 12% strand | O94925 |
| B | Isoform 3 of glutaminase kidney isoform, mitochondrial (EC 3.5.1.2) | protein | 392 | 48% helix, 12% strand | O94925 |
| C | Isoform 3 of glutaminase kidney isoform, mitochondrial (EC 3.5.1.2) | protein | 399 | 46% helix, 12% strand | O94925 |
| D | Isoform 3 of glutaminase kidney isoform, mitochondrial (EC 3.5.1.2) | protein | 403 | 48% helix, 11% strand | O94925 |
Ligands and binding sites
- GLN · Glutamine · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1180 | 0.74 | 0.77 | 88 | empty |
| 2 | 670 | 0.73 | 0.79 | 91 | GLN |
| 3 | 400 | 0.69 | 0.81 | 49 | empty |
| 4 | 72 | 0.61 | 0.90 | 18 | empty |
| 5 | 252 | 0.61 | 0.80 | 40 | empty |
Interfaces
4 interfaces between chains.
- A–D · 1647 Ų buried · 26 hydrogen bonds · protein-protein
- A–C · 687 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 223 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 143 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7SBM · Human glutaminase C (Y466W) with L-Gln, open conformation · the same entry in another collection · chain D against D, TM-score 1.00
- O94925 · AlphaFold monomer V2.0 prediction for glutaminase kidney isoform, mitochondrial (O94925) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O94925
- Elsewhere: RCSB PDB 7SBM · PDBe 7SBM · UniProt O94925
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