MolNFT v1 · #187381 · protein

Murine FAB/IGE in complex with profilin from hevea brasieliensis (hev B 8)

7SBG · FAB/IGE heavy chain: “Murine FAB/IGE in complex with profilin from hevea brasieliensis (hev B 8)”. X-ray diffraction, 2 ligands (NAG, FUC), 3 pockets (best druggability 0.65). MolNFT v1 #187381 on GenesisL1: 3D structure, binding…

PDB: 7SBG
Type: protein
Length: 547 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: FAB/IGE heavy chain; FAB/IGE light chain; Profilin-2
UniProt: Q9STB6
Ligands: NAG, FUC
Pockets: 3 · best druggability 0.65

Structure

x-ray diffraction · 3 distinct chains · 11% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	FAB/IGE heavy chain	protein	203	4% helix, 53% strand	—
L	FAB/IGE light chain	protein	211	7% helix, 52% strand	—
C	Profilin-2	protein	133	28% helix, 29% strand	Q9STB6

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains H
FUC · alpha-L-fucopyranose · sugar · chains H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	620	0.65	0.75	77	empty
2	105	0.48	0.80	21	empty
3	110	0.45	0.78	17	empty

Interfaces

3 interfaces between chains.

H–L · 1420 Å² buried · 12 hydrogen bonds · protein-protein
L–C · 569 Å² buried · 11 hydrogen bonds · protein-protein
H–C · 425 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

7SBG · Murine Fab/IgE in complex with profilin from Hevea brasieliensis (Hev b 8) · the same entry in another collection · chain H against H, TM-score 1.00
Q9STB6 · AlphaFold monomer V2.0 prediction for profilin-2 (Q9STB6) · a predicted model of the same protein · chain C against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9STB6
Elsewhere: RCSB PDB 7SBG · PDBe 7SBG · UniProt Q9STB6

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